Du Laboratory

Selected Publications

*co-first author 
# co-corresponding author 

Ruan Z*, Osei-Owusu J*, Du J, Qiu Z#, Lü W#. 2020. Structures and pH-sensing mechanism of the proton-activated chloride channel. Nature.

Ruan Z, Orozco IJ, Du J#, Lü W#. 2020. Structures of human Pannexin 1 reveal ion pathways and mechanism of gating. Nature.

Huang Y, Fliegert R, Guse AH, Lü W#, Du J#. 2019. A structural overview of the ion channels of the TRPM family. Cell Calcium.

Choi W*, Clemente N*, Sun W, Du J#, Lü W#. 2019. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature.

Yu J, Zhu H, Lape R, Greiner T, Shahoei R, Wang Y, Du J, Lü W, Tajkhorshid E, Sivilotti L, Gouaux E. In press. Mechanism of gating and partial agonist action in the glycine receptor. BioRxiv.

Haung Y, Roth B, Lü W#, Du J#. 2019. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. eLife.

Haley E, Choi W, Fan C, Sun W, Du J, Lü W. 2019. Expression and purification of the human lipid-sensitive cation channel TRPC3 for structural determination by single-particle cryo-electron microscopy. J Vis Exp (143):e58754, doi:10.3791/58754.

Huang Y, Winkler PA, Sun W, Lü W#, Du J#. 2018. Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature.

Fan C*, Choi W*, Sun W, Du J#, Lü W#. 2018. Structure of the human lipid-gated cation channel TRPC3. eLife:e36852.

Winkler PA*, Huang Y*, Sun W*, Du J, Lü W. 2017. Electron cryo-microscopy structure of a human TRPM4 channel. Nature.         

Lü W*, Du J*, Goehring A, Gouaux E. 2017. Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation. Science 355.

Du J*, Lü W*,Wu S, Cheng Y, Gouaux E. 2015. Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature 526(7572):224–229.

Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E. 2014. Structures of NMDA receptor reveal subunit arrangement and pore architecture. Nature 511(7508):191–197.

Lü W, Du J, Schwarzer N, Wacker T, Andrade SLA, Einsle O. 2013. The formate/nitrite transporter family of anion channels. Biol Chem 394(6):715–727.

Lü W, Schwarzer N, Du J, Gerbig-Smentek E, Andrade SLA, Einsle O. 2012. Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium. Proc Natl Acad Sci U S A 109(45):18395–18400.

Lü W, Du J, Schwarzer N, Gerbig-Smentek E, Einsle O, Andrade SLA. 2012. The FNT family channel FocA exports the products of mixed-acid fermentation. Proc Natl Acad Sci U S A 109(33):13254–13259.

Du J*, Say R*, Lu Ẅ, Fuchs G, Einsle O. 2011. Active site remodeling in the bifunctional fructose–1,6–bisphosphate aldolase/phosphatase. Nature 478(7370):534–537.

Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SLA, Einsle O. 2011. Mechanism of gating in the formate channel FocA from Salmonella typhimurium. Science 332:352–354.

Lü W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O. 2010. Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila. J Mol Biol 396(2):321–331.