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Publications

Du Laboratory

Selected Publications

*co-first author
# co-corresponding author

Ruan Z, Haley E, Orozco IJ, Sabat M, Myers R, Roth R, Du J#, Lü W#. Pre-print. Structures of TRPM5 channel elucidate mechanism of activation and inhibition. bioRxiv.

Yu J*, Zhu HT*, Lape R, Greiner T, Du J, Lü W, Sivilotti L#, Gouaux E#. 2021. Mechanism of gating and partial agonist action in the glycine receptorCell.

Ruan Z*, Osei-Owusu J*, Du J, Qiu Z#, Lü W#. 2020. Structures and pH-sensing mechanism of the proton-activated chloride channel. Nature.

Ruan Z, Orozco IJ, Du J#, Lü W#. 2020. Structures of human Pannexin 1 reveal ion pathways and mechanism of gating. Nature.

Huang Y, Fliegert R, Guse AH, Lü W#, Du J#. 2019. A structural overview of the ion channels of the TRPM family. Cell Calcium.

Choi W*, Clemente N*, Sun W, Du J#, Lü W#. 2019. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature.

Haung Y, Roth B, Lü W#, Du J#. 2019. Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel. eLife.

Haley E, Choi W, Fan C, Sun W, Du J, Lü W. 2019. Expression and purification of the human lipid-sensitive cation channel TRPC3 for structural determination by single-particle cryo-electron microscopy. J Vis Exp (143):e58754, doi:10.3791/58754.

Huang Y, Winkler PA, Sun W, Lü W#, Du J#. 2018. Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium. Nature.

Fan C*, Choi W*, Sun W, Du J#, Lü W#. 2018. Structure of the human lipid-gated cation channel TRPC3. eLife:e36852.

Winkler PA*, Huang Y*, Sun W*, Du J, Lü W. 2017. Electron cryo-microscopy structure of a human TRPM4 channel. Nature.

Lü W*, Du J*, Goehring A, Gouaux E. 2017. Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation. Science 355.

Du J*, Lü W*,Wu S, Cheng Y, Gouaux E. 2015. Glycine receptor mechanism elucidated by electron cryo-microscopy. Nature 526(7572):224–229.

Lee CH, Lü W, Michel JC, Goehring A, Du J, Song X, Gouaux E. 2014. Structures of NMDA receptor reveal subunit arrangement and pore architecture. Nature 511(7508):191–197.

Lü W, Du J, Schwarzer N, Wacker T, Andrade SLA, Einsle O. 2013. The formate/nitrite transporter family of anion channels. Biol Chem 394(6):715–727.

Lü W, Schwarzer N, Du J, Gerbig-Smentek E, Andrade SLA, Einsle O. 2012. Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium. Proc Natl Acad Sci U S A 109(45):18395–18400.

Lü W, Du J, Schwarzer N, Gerbig-Smentek E, Einsle O, Andrade SLA. 2012. The FNT family channel FocA exports the products of mixed-acid fermentation. Proc Natl Acad Sci U S A 109(33):13254–13259.

Du J*, Say R*, Lu Ẅ, Fuchs G, Einsle O. 2011. Active site remodeling in the bifunctional fructose–1,6–bisphosphate aldolase/phosphatase. Nature 478(7370):534–537.

Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SLA, Einsle O. 2011. Mechanism of gating in the formate channel FocA from Salmonella typhimurium. Science 332:352–354.

Lü W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O. 2010. Structural basis of the action of glucosyltransferase Lgt1 from Legionella pneumophila. J Mol Biol 396(2):321–331.